The 15 Best Hydrolyzed Dog Foods 2025: Vet-Approved

This content was reviewed and fact-checked by veterinarian Dr. Sandra Tashkovska, DVM.

Imagine feeding your dog something that looks like food, smells like food, and even tastes like food—but their immune system still sees it as a threat. That’s the daily struggle for dogs with food sensitivities and allergies. Hydrolyzed dog food isn’t just another marketing buzzword—it’s a clinically backed solution that could mean the difference between constant itching, digestive distress, and finally letting your dog live in peace. But here’s the twist: not all hydrolyzed diets are created equal. Some require a prescription. Others don’t. And with confusing labels and wildly different price points, how do you know which formula actually works, and which is just clever packaging? In this guide, we review the best hydrolyzed dog foods on the market, explain why they work, and help you choose the right option for your dog.

How Does Hydrolysed Dog Food Work?

Hydrolyzed dog food works by breaking down proteins into their smallest components—amino acids and small peptides—through a process called hydrolysis, which uses water, enzymes, or heat to cleave protein bonds. This reduces the proteins to fragments so small (often < 3–10 K Daltons) that they become unrecognizable to a dog’s immune system, minimizing allergic reactions triggered by intact proteins.

*Daltons (Da) measure molecular weight; smaller = less likely to trigger allergies.

Stages of Hydrolyzed Dog Food:

The Benefits According to Science

Accordingly to the latest research, hydrolyzed dog food can benefit your dog’s nutrition in many ways:

1. Higher nutrient absorption: A study published in the Journal of Animal Science Diets found that hydrolyzed salmon is more digestible, maintains normal blood parameters, and improves skin barrier function in adult dogs compared to chicken meal.^[1]
2. Enhances protein quality: Researchers found that diets using hydrolyzed chicken proteins achieved Digestible Indispensable Amino Acid Scores (DIAAS-like values) exceeding 100%, indicating no amino acid deficiencies and meeting all nutritional requirements for dogs. In contrast, regular whole chicken protein dog food didn’t do this as well—it often lacked enough of an amino acid called tryptophan, which dogs need to stay healthy.^[2]
3. As effective as alternative therapeutic dog diet: Hydrolyzed protein-based dog food can manage adverse food reactions (AFR) in dogs as effectively as diets incorporating novel proteins like egg, along with phytonutrients (plant-based nutrients).^[3]
4. Better gut health indicators: An analysis of five different dog hydrolyzed diets reveleaed that dogs dogs on them had healthier poop. Their feces had fewer smelly, harmful compounds that usually come from proteins not being digested properly. This means their bodies were digesting protein more efficiently, and less harmful substances were accumulating in their intestines.^[4]
5. Better for long-term relief compared to other diets: A study involving 26 dogs with chronic small intestinal disease randomly assigned the dogs to either a hydrolyzed protein diet or a highly digestible control diet. The results showed that a hydrolyzed protein diet is highly effective for the long-term management of chronic small intestinal disease in dogs. It not only helps reduce symptoms initially but also helps maintain a symptom-free status for a longer period compared to standard highly digestible diets.^[5]

Always work with your vet before changing your dog’s diet. Alternatively, you can get personalized nutritional advice from an online registered vet nutritionist through platforms like Vetster anytime, anywhere. You can also chat with an online vet to discuss whether a hydrolyzed protein diet is appropriate for your dog’s symptoms. Additionally, an at-home dog gut health test can provide valuable insights into your dog’s microbiome, helping determine what nutrients your dog’s diet should contain and if a hydrolyzed formula might be beneficial. Similarly, at-home food allergy tests can help identify specific food allergens, making it easier to choose the most effective hydrolyzed recipe with ingredients that will not trigger allergies.

Best Hydrolyzed Food For Dogs

Here are the best hydrolyzed dog foods of this year.

Best Overall Hydrolyzed Dog Food

Flavor: Natural

Protein: 19%

Fat: 17%

Fiber: 3%

Diet: AAFCO

Why we recommended it: Royal Canin’s Hydrolyzed Protein HP stands out because it’s backed by veterinary science and formulated to minimize immune reactions. The hydrolyzed soy protein is broken into tiny peptides, making it easier to digest and less likely to trigger allergies compared to whole proteins. Additionally, the inclusion of omega-3 fatty acids (EPA and DHA) supports skin health, while a blend of soluble and insoluble fibers helps regulate digestion. User feedback highlights its effectiveness at resolving chronic issues and allergy symptoms within a few weeks. This formula is safe for long-term use in the diet.

What sets it apart from competitors: Unlike some hydrolyzed diets that use animal proteins (which can still cause reactions), Royal Canin opts for hydrolyzed soy protein, which is less allergenic. It also includes chelated minerals for better absorption and prebiotics (fructooligosaccharides) to promote gut health. Competitors often lack a dual focus on both skin and digestive support.

Best Non-Prescription Hydrolyzed Dog Food

Flavor: Pork – Rice

Protein: 22%

Fat: 11%

Fiber: 3.5%

Diet: AAFCO

Why we recommended it: SquarePet VFS features hydrolyzed pork protein (a novel, easily digestible source) with omega-3 fatty acids (DHA/EPA) for skin health and a limited-ingredient formula to minimize triggers. Unlike many competitors, it’s made in the USA in an SQF-certified facility in Minnesota, ensuring high safety standards. Additionally, it avoids artificial additives, appealing to owners who prioritize natural nutrition. Users report noticeable improvements—dogs with IBD show fewer flare-ups, and pets with skin allergies experience reduced scratching within weeks. The inclusion of brown rice as a primary carbohydrate and the addition of flaxseed oil for fiber further support digestive health.

What sets it apart from competitors: While brands like Royal Canin or Purina Pro Plan require prescriptions, SquarePet VFS delivers similar benefits without the vet hassle. Its hydrolyzed pork protein is rarer than that of chicken or soy-based options, reducing the risk of cross-reactivity for dogs with common meat allergies.

Best Hydrolyzed Dog Food for Sensitive Skin

Flavor: Pea & salmon

Protein: 22%

Fat: 12%

Fiber: 4.5%

Diet: AAFCO

Why we recommended it: Diamond CARE stands out because it combines hydrolyzed salmon (a novel, easily digestible protein) with a grain-free, limited-ingredient formula to minimize triggers. The omega-3 and omega-6 fatty acid blend (2.5% and 0.8%, respectively) is clinically shown to improve skin and coat health, while K9 Strain Probiotics (80 million CFU/lb) support digestion and immunity. It also packs a blend of antioxidants, including zinc, selenium, and vitamin E, to support the immune system.​ We love it because no prescription is required, making it more accessible to dog owners.

What sets it apart from competitors: Features a limited-ingredient, grain-free, and potato-free formulation that further reduces the risk of adverse reactions. The use of peas and pea flour provides high-quality carbohydrates, while the absence of common allergens makes it suitable for dogs with specific dietary needs.

Best Hydrolyzed Dog Food for Sensitive Stomachs

Flavor: Chicken

Protein: 14.5%

Fat: 10%

Fiber: 6%

Diet: AAFCO

Why we recommended it: Hill’s z/d is clinically proven to reduce adverse food reactions, with hydrolyzed chicken liver and chicken protein broken down into tiny, hypoallergenic peptides that are less likely to trigger immune responses. It also includes ActivBiome+, a proprietary prebiotic blend that supports gut health and promotes firmer stools—a game-changer for dogs with chronic diarrhea or inflammatory bowel disease (IBD). The formula also includes a single purified carbohydrate source—cornstarch—to further reduce potential allergens. Additionally, it’s enriched with omega-3s and vitamin E to help repair skin barriers affected by food-related allergy symptoms.

What sets it apart from competitors: The diet is formulated without gluten, soy protein, lactose, artificial colors, flavors, or preservatives, making it suitable for dogs with multiple food sensitivities. Furthermore, it promotes a urinary environment that reduces the risk of developing struvite and calcium oxalate crystals, addressing urinary health concerns while also addressing food sensitivities.

Best Hydrolyzed Dog Food for Small Dogs

Flavor: Natural

Protein: 22%

Fat: 14%

Fiber: 2.6%

Diet: AAFCO

Why we recommended it: ​Royal Canin Hydrolyzed Protein Small Dog provides prescription-grade hydrolyzed protein without animal-based allergens, relying instead on plant-based soy—ideal for dogs reactive to poultry or red meat. The inclusion of B vitamins, EPA, and DHA reinforces the skin barrier and promotes a healthy coat, addressing dual dermatological and digestive issues common in sensitive small breeds. Its proprietary fiber blend, which includes beet pulp and fructooligosaccharides, supports digestion and stool quality.

What sets it apart from competitors: Addresses the unique needs of small dogs with breed-specific kibble size, specifically engineered for miniature jaws, and a formulation tailored to their metabolic needs. Additionally, it employs Relative Supersaturation (RSS) methodology to minimize the risk of urinary crystal formation.

Best Hydrolyzed Dog Food for Senior Dogs

Flavor: Salmon & Chicken

Protein: 20%

Fat: 9.5%

Fiber: 4%

Diet: AAFCO

Why we recommended it:​ Purina Pro Plan Veterinary Diets HA features hydrolyzed soy protein isolate and hydrolyzed chicken liver and giblets, which provide easily digestible, low-allergen protein to minimize immune reactions. The inclusion of coconut oil, a source of medium-chain triglycerides, supports alertness, cognitive function, and energy levels in older dogs, while powdered cellulose aids digestion and stool quality. Its single carbohydrate source (corn starch) reduces ingredient complexity, lowering the risk of triggering sensitivities.

What sets it apart from competitors: The prescription-grade formulation is backed by Purina’s research to be suitable for dogs with food allergies, gastroenteritis, dermatitis, food intolerance, inflammatory bowel disease, or pancreatitis.

Best Hydrolyzed Dog Food for Puppies

Flavor: Beef

Protein: 30%

Fat: 20%

Fiber: 4.5%

Diet: AAFCO

Why we recommended it: Next Level HI-PRO 30 LS stands out for its triple-protein blend (hydrolyzed chicken, beef meal, and menhaden fish meal), which delivers 30% crude protein—higher than most puppy foods—to fuel rapid growth without common allergens. The inclusion of omega-3s (0.75%) and omega-6s (3.5%) promotes brain development and a shiny coat, while prebiotics (dried chicory root) and probiotics support digestive health, a common concern for puppies transitioning to solid food. It’s SQF-certified, with tighter mineral controls than typical puppy diets, which reduces the risk of deficiencies. Owners report that puppies “love the taste” despite being typically picky during weaning.

What sets it apart from competitors: Offer joint-supporting nutrients (glucosamine from chicken meal and flaxseed) and the VX Advantage blend—a proprietary mix of selenium yeast, vitamins, and prebiotics for immune and metabolic support. Additionally, the inclusion of L-carnitine supports fat metabolism. It’s non-prescription.

Best Canned Hydrolyzed Dog Food

Flavor: Natural

Protein: 22%

Fat: 6.6%

Fiber: 21%

Diet: AAFCO

Why we recommended it: Royal Canin Hydrolyzed Protein Loaf Canned uses hydrolyzed soy protein—broken into low-molecular-weight peptides to minimize allergenicity—paired with hydrolyzed chicken liver for palatability without compromising hypoallergenic benefits. The inclusion of B vitamins, EPA, and DHA reinforces the skin barrier and reduces inflammation, addressing both dermatological and digestive symptoms. A proprietary fiber blend, including powdered cellulose, supports gut health and stool quality, which is critical for dogs with chronic diarrhea.

What sets it apart from competitors: It’s particularly effective for dogs who’ve struggled with vomiting, diarrhea, or skin flare-ups triggered by intact proteins, serving as both an elimination diet and long-term solution for immune-mediated reactions. Royal Canin adheres to strict manufacturing protocols to prevent cross-contamination, a rarity in hydrolyzed diets.

Best Grain-Free Hydrolyzed Dog Food

Flavor: Salmon

Protein: 24%

Fat: 12%

Fiber: 5%

Diet: AAFCO

Why we recommended it: Blue Buffalo’s HF Hydrolyzed grain-free, limited-ingredient formula reduces exposure to common triggers like corn, wheat, and soy. The hydrolyzed salmon protein offers a novel protein alternative, making it easier to digest and less likely to provoke allergies compared to other meat-based hydrolyzed proteins. It also includes omega-3 fatty acids, derived from fish oil and flaxseed, to support skin health, as well as prebiotics (dried chicory root) to promote gut flora.

What sets it apart from competitors: Clinical studies cited by Blue Buffalo demonstrate high digestibility and ideal stool quality, which is critical for dogs with sensitive stomachs. It also packs antioxidant-rich ingredients like pumpkin and kelp to bolster the immune system.

Best Hydrolyzed Dog Food For Picky Eaters

Flavor: Cod, seafood & fish

Protein: 17.5%

Fat: 14%

Fiber: 2.9%

Diet: AAFCO

Why we recommended it: ​Farmina Vet Life Hydrolyzed Protein Derma Formula combines hydrolyzed fish protein (a novel, easily digestible source) with herring oil for skin health and a limited-ingredient formula to minimize triggers. It’s free from grains and common allergens like chicken or beef, reducing the risk of reactions. The inclusion of omega-3 fatty acids helps soothe itchy skin, while prebiotics, such as those found in quinoa seeds, support gut health. Owners report that even notoriously picky dogs often “lick the bowl clean”, a rarity with hypoallergenic foods. Veterinarians often prescribe it as part of an elimination diet for dogs with recurrent diarrhea or skin flare-ups linked to protein sensitivities.

What sets it apart from competitors: The low molecular weight (6,000 daltons) of its hydrolyzed proteins ensures a minimal immune response, because these protein fragments are small enough (under 10,000 daltons) to evade recognition by the immune system, making it a top choice for dogs with severe allergies.

Best Hydrolyzed Dog Food for IBD

Flavor: Wild-caught anchovy

Protein: 22%

Fat: 6.6%

Fiber: 21.2%

Diet: AAFCO

Why we recommended it: Forza10 Active Colon combines hydrolyzed Icelandic anchovy protein with anti-inflammatory ingredients such as rosemary and yucca extract to soothe an irritated gut. Its comprehensive formulation addresses multiple aspects of gastrointestinal health. The diet is free from GMOs, by-products, wheat, soy, and artificial preservatives, colors, or flavors, making it suitable for dogs with various food sensitivities. Furthermore, the product can be introduced without a transition period, simplifying dietary changes for sensitive dogs.

What sets it apart from competitors: The inclusion of prebiotics (FOS) and omega-3s (3.6%) supports gut flora balance and reduces intestinal inflammation, with many owners reporting firmer stools and fewer flare-ups within days  For dogs with IBD needing gentle, effective nutrition, Forza10 Active Colon delivers vet-quality care without the prescription hassle. 

Best Alternative to Hydrolyzed Dog Food

Flavor: Veggie Supreme

Protein: 28%

Fat: 11%

Fiber: 5%

Diet: AAFCO

Why we recommended it: ​Wild Earth Vegan Dry Dog Food Performance Formula is particularly beneficial for dogs with allergies or intolerances to meat, dairy, or wheat, offering a plant-based diet that meets their nutritional needs.​ We recommend this formula because it utilizes dried yeast and potato protein as primary protein sources, providing all essential amino acids required for canine health. The inclusion of superfoods like oats, spinach, pumpkin, and sweet potato contributes to a holistic and nutritious diet. Additionally, the formula contains omega-3 and omega-6 fatty acids, DHA, taurine, and L-carnitine to support healthy skin, brain development, and cardiovascular function.

What sets it apart from competitors: Commitment to sustainability and ethical sourcing. Moreover, the plant-based formulation requires less water and emits fewer greenhouse gases compared to traditional meat-based kibbles, making it an environmentally friendly choice.

Other Hydrolyzed Dog Foods

Alternative Diets

Although hydrolyzed diets are designed to prevent triggering food allergies, this study found that nearly one in three dogs with allergies still experienced an immune response to them.^[6] That means these diets aren’t a guaranteed fix for every dog with food sensitivities.

Here are the best alternatives to hydrolyzed dog diets:

• Sensitive stomach diets: A great alternative to hydrolyzed food for dogs with mild digestive issues, these diets use highly digestible ingredients and probiotics to support gut health without requiring protein breakdown.

• Freeze-dried diets: Ideal for pet owners seeking a minimally processed option, freeze-dried raw food delivers high nutrient retention and fewer additives—making it suitable for dogs with chemical sensitivities instead of protein allergies.

• Hypoallergenic diets: These formulas often include novel proteins and are designed specifically to reduce immune reactions, making them the closest and most direct alternative to veterinary hydrolyzed diets.

• Raw diets: For dogs with intact digestive systems but chronic skin or food intolerance issues, raw diets offer a biologically appropriate, allergen-free alternative when hydrolyzed foods are either unavailable or not tolerated.

• Fresh diets: Gently cooked, human-grade meals can be tailored to avoid allergens while offering better ingredient transparency than hydrolyzed kibble—ideal for dogs with sensitivities not linked to protein structure.

• Allergy-friendly diets: Featuring limited ingredients and novel proteins, these foods help isolate allergens and soothe symptoms—offering a targeted but non-hydrolyzed approach to managing food allergies.

The Bottom Line

Choosing the best hydrolyzed dog food isn’t just about picking a product with a fancy label—it’s about finding real relief for your dog’s discomfort. Whether your pup struggles with chronic itching, relentless GI issues, or suspected food allergies, the right hydrolyzed formula can be life-changing. However, remember that effectiveness depends on the quality of ingredients, proper diagnosis, and consistency. Now that you know what to look for, you’re one step closer to giving your dog the comfort they deserves. Consult with your vet, review our top picks, and trust the science—because when it comes to your dog’s health, settling for “good enough” isn’t an option.

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Sources

Canine Bible uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process and product review methodology to learn more about how we fact-check, test products, and keep our content accurate, reliable, and trustworthy.

1. 297 Digestibility, blood parameters, and skin barrier function of dogs fed hydrolyzed salmon proteins 
2. 127 Standardized Amino Acid Digestibility and Protein Quality of Extruded Canine Diets Containing Hydrolyzed Protein
3. Successful nutritional control of scratching and clinical signs associated with adverse food reaction: A randomized controlled COSCAD’18 adherent clinical trial in dogs in the United States
4. The effects of hydrolyzed protein on macronutrient digestibility, fecal metabolites and microbiota, oxidative stress and inflammatory biomarkers, and skin and coat quality in adult dogs
5. A Randomized, Open-Label, Positively-Controlled Field Trial of a Hydrolyzed Protein Diet in Dogs with Chronic Small Bowel Enteropathy
6. Hydrolyzed diets may stimulate food-reactive lymphocytes in dogs