Best CBD Oil for Dogs with Anxiety 2025: A Natural Calming Solution

This content was reviewed and fact-checked by veterinarian Dr. Aukse Caraite, DVM.

Every thunderstorm, car ride, or unexpected visitor turns your lovable pup into a trembling mess. You’ve tried training, calming treats, even those awkward doggy compression shirts—yet nothing seems to truly ease their stress. Here’s the surprising part: CBD oil could be the game-changer you’ve been searching for. But with countless products flooding the market, how do you know which CBD oil is effective and which are just overpriced gimmicks? Some brands promise instant relief, while others warn it takes weeks to see results. So, what’s the truth? In this guide, we’ll break down the best CBD oils for dogs with anxiety, backed by real results, expert insights, and what to look for before making a purchase. Let’s dive in if you’re ready to help your dog feel calm, safe, and happy again.

What Is CBD Oil?

CBD oil, or cannabidiol oil, is a natural extract derived from the hemp plant (Cannabis sativa). It is one of many compounds found in cannabis but is non-psychoactive, meaning it won’t get your dog “high” like THC (tetrahydrocannabinol), the primary psychoactive component in marijuana. The key difference between CBD and THC is how they interact with the body. While THC affects the brain’s receptors to create a “high,” CBD works differently, promoting relaxation and wellness without any intoxicating effects. That’s why CBD oil is considered safe for pets when used correctly.

Common Symptoms of Anxiety in Dogs

How Does CBD Work on Dogs with Anxiety?

CBD interacts with your dog’s endocannabinoid system (ECS), a network of receptors that helps regulate mood, stress, sleep, and overall balance in the body. This system plays a crucial role in keeping your dog calm and emotionally stable. When a dog experiences anxiety, their ECS can become imbalanced, leading to heightened stress responses. CBD helps by supporting this system, promoting relaxation, and reducing nervous behaviors without sedating your pup.

The Science Behind CBD Oil & Dog Anxiety

While still developing, current research offers insights into its effectiveness, though findings are mixed.

Scientific Studies

1. Single-Dose CBD Study (2023): A randomized, placebo-controlled, blinded study investigated the effects of a single oral dose of THC-free CBD (4 mg/kg body weight) on dogs subjected to stress-inducing scenarios, such as car travel and separation. Results indicated that dogs receiving CBD exhibited significantly lower cortisol levels, reduced whining, and appeared more relaxed compared to the placebo group. This suggests that CBD may alleviate acute stress in certain situations.
2. Behavioral Response Study (2020): Another study assessed CBD’s impact on dogs exposed to fear-inducing stimuli. Administering 1.4 mg/kg of CBD 4–6 hours before testing did not produce a significant anxiolytic effect, indicating that CBD’s efficacy may vary depending on dosage, timing, or the nature of the anxiety-inducing event.
3. Shelter Dog Study (2021): Research focusing on shelter dogs evaluated the effects of CBD (~1.25 mg/kg once daily for 45 days) on stress-related behaviors. Findings showed a decrease in aggressive behavior toward humans in the CBD group, though the reduction was not statistically significant. Other stress indicators, such as displacement activities and stereotypes, remained unchanged. 

Anecdotal Evidence

Many dog owners have reported improvements in their pets’ anxiety symptoms after administering CBD oil. For instance, some have observed reduced fear during thunderstorms or decreased separation anxiety. However, these accounts are subjective and may be influenced by individual perceptions. 

The Benefits

Here’s how CBD may help dogs with anxiety:

• Calms the nervous system
• Reduces stress hormones
• Promotes relaxation
• Encourages better sleep

The veterinary community remains cautious regarding CBD use for canine anxiety. While some veterinarians acknowledge potential benefits, they emphasize the need for more comprehensive research to determine optimal dosages, long-term effects, and possible drug interactions. Pet owners must consult with a veterinarian before introducing CBD into their dog’s regimen. Read our scientific-based article on all things CBD for dogs to learn more about the benefits and research.

Best CBD Oil For Dogs With Anxiety

These are our top picks for the best CBD oil for dogs suffering from anxiety.

Best Overall CBD Oil For Dogs With Anxiety

CBD type: Full-spectrum

Price: $25.95 – $144.95

Oil source: USA, CO

THC: 0%

Potency (mg): 150, 300, 600, 1200 & 3000

Why we recommended it: HolistaPet CBD takes the top spot as the best overall CBD for dogs with anxiety. All their products are made from 100% organic, cruelty-free, and vegan ingredients. Every CBD batch is lab-tested by a third party to ensure their oils’ safety, quality, and potency.

What sets it apart from competitors: This company stands out because its CBD oils are combined with organic superfoods like hemp seeds, L-theanine, chamomile, turmeric root, Boswellia, flaxseed, and more for enhanced benefits. CBD and these superfoods create a more potent concentration that may yield fast results.

Key Features

Save an extra 25% – 30% if you sign up for auto shipping. Just use this link to get started.

Best Health Specialized Line For Dogs With Anxiety

CBD type: Full-spectrum

Price: $39.95 – $99.95

Oil source: USA, CO

THC: Less than 0.3%

Potency (mg): 125, 250, 500 & 1000

Why we recommended it: Honest Paws CBD oil for dogs offers CBD drops to treat particular health concerns, such as anxiety, joint pain, inflammation, stress, overall health, and other common pet ailments.

What sets it apart from competitors: All its ingredients are sourced, produced, and shipped under human-grade regulations. Plus, their CBD oils for dogs are complemented by the superfood qualities of hemp seed oil, which is packed with essential vitamins, minerals, omega fatty acids, proteins, and fiber.

Key Features

Get 15% off at Honest Paws with coupon code CANINEBIBLE. Use this link to get started.

My Video Review Experience

Best Isolate CBD Oil For Dogs With Anxiety

CBD type: Isolate

Price: $19.99 – $39.99

Oil source: USA, KY

THC: 0%

Potency: 150mg, 300mg & 750mg

Why we picked and recommended it: Medterra Pet CBD oils won our pick for the best isolate CBD oil for dogs with anxiety. They use human-grade CBD isolate oil in their product formulations and MCT oil derived from coconuts as the carrier oil, which helps absorb CBD and provides additional health benefits. They back their CBD oils’ quality and safety with a corresponding Certificate of Analysis, which you can access on their website. This leads to a dedicated landing page containing information on each product batch, ingredient profiles, and quality control methods.

What sets it apart from competitors: It’s made with industrial hemp grown and extracted according to the Kentucky Department of Agriculture’s strict guidelines.

Key Features

My Video Review Experience

Get 25% off at Medterra with the coupon code CANINEBIBLE. Just use this link to get started.

More Options

Finding the right CBD oil for your dog’s anxiety is essential to ensuring the best results. With various brands offering different formulations, potencies, and ingredients, choosing one that suits your dog’s specific needs is important. Whether you’re looking for organic hemp extracts, fast-acting formulas, or veterinarian-recommended options, we’ve compiled a list of the top CBD oils for dogs to help you make the best choice. Read our full guide to the best CBD oils for dogs for other alternatives.

How Long Does CBD Take to Help With Anxiety in Dogs?

CBD oil typically starts working within 30-60 minutes for situational anxiety, while chronic anxiety may require consistent use for 1-2 weeks to see full benefits. Factors like dosage, your dog’s size, and the severity of their anxiety all play a role in how quickly it takes effect.

💡 Want to learn more? Read our in-depth guide:
👉 How Long Does CBD Stay in a Dog’s System?
👉 How Long Does It Take for CBD to Work on Dogs?

CBD Dosage for Dogs with Anxiety

The right CBD dosage depends on your dog’s weight, anxiety level, and how they respond to CBD. A general rule of thumb:

• Mild Anxiety: 0.25 mg per pound
• Moderate Anxiety: 0.5 mg per pound
• Severe Anxiety: 1 mg per pound

For best results, start with a low dose and gradually increase while monitoring your dog’s response.

📌 Need a detailed dosage chart? Check out our full guide:
👉 The Ultimate CBD Dosage Guide for Dogs (Infographic)

Other CBD Products to Treat Anxiety In Dogs

The Bottom

Watching your dog struggle with anxiety is heartbreaking—but the right CBD oil can make all the difference. The key is choosing a high-quality product with the right ingredients, dosage, and third-party testing to ensure safety and effectiveness. Not every CBD oil is created equal, and what works for one dog may not work for another. That’s why it’s worth experimenting (under vet guidance) to find the perfect fit for your pup’s unique needs. If you’re ready to take the next step, start with one of the highly-rated options we’ve covered. Your dog deserves to feel calm, safe, and happy—without fear ruling their world.

---

Like It? Subscribe & Share!

* indicates required

First Name *

Email Address *

Dog Breed

Leave this field empty if you’re human:

Sources

Canine Bible uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process and product review methodology to learn more about how we fact-check, test products, and keep our content accurate, reliable, and trustworthy.